• A disfun o cognitiva p s operat ria uma s

  2023-07-31

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma Thonzonium Bromide receptor disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma qu

• Thus we presumed that ALDH A might play an

  2023-07-31

  

  Thus, we presumed that ALDH1A3 might play an important role in TMZ-chemoresistance in glioblastoma patients. As we expected, the glioblastoma cell lines and primary glioma Gramine were more sensitive to TMZ treatment when ALDH1A3 was inhibited or depleted. Consistently, it has been shown that downr

• br Hypoadiponectinemia in metabolic syndrome APN belongs str

  2023-07-31

  

  Hypoadiponectinemia in metabolic syndrome APN belongs structurally to the complement 1q family and is found at high concentrations (>0.01% of total protein) in the serum of healthy individuals [6]. Given the abundance of APN in plasma, it is assumed that alterations in plasma levels of APN might

• br Results br Discussion The

  2023-07-29

  

  Results Discussion The AM251 cytoskeleton is a highly attractive target for many bacterial toxins, owing to its role in activation and locomotion of immune cells, secretion of humoral response factors, and maintenance of protective barriers at the cellular (sub-membrane cytoskeleton) and organ

• br Acknowledgements This work was supported by the

  2023-07-29

  

  Acknowledgements This work was supported by the National Key Technology Research and Development Program (2012BAD19B01) and General Financial Grant from the China Postdoctoral Science Foundation (2015M581754). Introduction Cough is one of the most important defensive reflex brought into actio

• Until now five muscarinic receptor M genes have been

  2023-07-29

  

  Until now, five muscarinic receptor (M1-5) genes have been cloned, but, M1-3 receptors are functionally recognized in the lungs. Smooth muscle contraction is mainly mediated by M3. M2 may also participate in the contraction via Gi protein which leads to a decrease in cAMP. On the other hand, M2 is l

• The presence of different LO splice variants was

  2023-07-29

  

  The presence of different 5-LO splice variants was first demonstrated in human p2y inhibitor tumour cells and in dimethyl sulfoxide-differentiated HL-60 cells [40] and a correlation between the 5-LO splicing pattern and the malignancy of the brain tumours was found. Later, other splice variants wer

• br Disclosure br Acknowledgement br Introduction

  2023-07-29

  

  Disclosure Acknowledgement Introduction CYP17A1 is a multifunctional enzyme with both 17α-hydroxylase and 17,20-lyase activities and is essential for the biosynthesis of steroidal Ezatiostat hydrochloride in male testes and adrenal glands. The 17α-hydroxylase activity of CYP17A1 is involve

• Aurora A overexpression is also

  2023-07-29

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer dnmt [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene products and proteins in

• Acknowledgments br Introduction Prostate cancer is the first

  2023-07-29

  

  Acknowledgments Introduction Prostate cancer is the first leading cause of cancer-related deaths among males in the UK and the second in the US. Despite recent advances in surgery, radiation, medical management and screening, prostate cancer patients suffer high morbidity and mortality and signi

• Among steroid saponins ginsenosides are the active component

  2023-07-29

  

  Among steroid saponins, ginsenosides are the active components of ginseng, a well-known chinese medicinal plant. More than hundreds of different ginsenosides have been isolated from ginseng and have shown in the past to be membrane active substances and to influence the membrane by modulating lipid

• ARG I is one of the

  2023-07-29

  

  ARG I is one of the most important mammalian enzymes responsible for nitrogen metabolism since it comprises the main route for the elimination of excess nitrogen resulting from amino amyloid and nucleotide metabolism [18]. ARG I deficiency leads to hyperargininemia, characterized by progressive neu

• There is a delicate balance between ROS

  2023-07-29

  

  There is a delicate balance between ROS generation and scavenging by the protective antioxidant defenses in the cell. Antioxidant systems present in the BPTES include enzymes like superoxide dismutase (SOD), catalases, glutathione peroxidases (GPxs) and peroxiredoxins (PRxs) (Fig. 3) [38]. SODs are

• br Apelin The APJ receptor ligand

  2023-07-29

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino Coumarin residues that are cleaved into biologically active C-terminal fragments of various size

• LY2584702 On the contrary Birrel and colleagues

  2023-07-29

  

  On the contrary, Birrel and colleagues observed divergent proliferative responses to androgens in different BC cell lines: DHT and mibolerone were found to inhibit the T47-D and ZR-75-1 LY2584702 growth, while the proliferation of MCF-7 cells was increased by both the androgens [53]. It is worth noy

16136 records 313/1076 page Previous Next First page 上5页 311312313314315 下5页 Last page