• The activity of MMPs is regulated at the level

  2023-03-17

  

  The activity of MMPs is regulated at the level of gene transcription or by the enzymatic activation of latent enzymes. Inflammatory cytokines such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6 are elevated in synovial fluid, synovium and cartilage in patients with OA, and these cyto

• Since primitive societies plants herbs

  2023-03-17

  

  Since primitive societies, plants, herbs and seeds, rich in phytochemicals, were used due to their benefits in human health. These molecules were shown to present a diverse array of action mechanisms, including antioxidant activity, enzyme stimulation, hormones mimicking and by interfering with DNA

• Phytoremediation technology is defined as the use

  2023-03-17

  

  Phytoremediation technology is defined as the use of plants to remove contaminants from soils or to render them harmless, and is regarded as a cost-effective, environmental-friendly method for reclaiming soils contaminated by toxic metals (Lasat, 2002, Mahar et al., 2016, Marrugo-Negrete et al., 201

• Many of the cellular processes regulated by AKT activation

  2023-03-17

  

  Many of the cellular processes regulated by AKT activation are also controlled by other intracellular pathways such as the MAPK pathway, the PLCγ pathway, but also, directly or indirectly, by signaling pathways not linked to RTK transmembrane receptors, such as growth factor-linked signaling affecti

• The inflammatory cytokine IL is

  2023-03-17

  

  The inflammatory cytokine IL-6 is an additional factor that has been hypothesized to contribute to epinephrine-mediated repression of drug detoxifying proteins such as CYP3A4 (Aninat et al., 2008). Indeed, this CYP is well-known to be repressed by IL-6 (Dickmann et al., 2011) and epinephrine has pre

• In this study an in vitro AChE inhibition assay

  2023-03-16

  

  In this study, an in vitro AChE inhibition assay combined with UF-HPLC-ESI-Q-TOF/MS method was developed for rapid screening and identification of AChEI from the roots of C. chinensis Franch. Five compounds was found with AChE inhibitory activity and identified by the on-line DAD-ESI-Q-TOF/MS compar

• Screening a selection of analogues from this library

  2023-03-16

  

  Screening a selection of analogues from this library against the panel of 26 kinases (16, 22, and 24 were screened at 30 μM due to poor solubility; 17 tested at 100 μM) generally demonstrated an increase in activity compared to endothelin receptor 3 (Fig. 3, Fig. 6). The benzamide analogue 16 demon

• br Materials and methods br Results and

  2023-03-16

  

  Materials and methods Results and discussion In our previous studies (Matarneh et al., 2017), mitochondria were mechanically disrupted and separated into supernatant and pellet fractions by centrifugation. The causative agent for enhnced glycolytic flux was shown to be a protein that resides i

• IWR-1-endo In the present study we showed that LOX

  2023-03-16

  

  In the present study, we showed that 15-LOX metabolites, which are the precursors of anti-inflammatory and pro-resolving lipid mediators, were decreased in the unaffected skin area of the OS model rats by comprehensive lipidomics analyses. Furthermore, subsequent microarray analyses demonstrated tha

• There is a delicate balance between ROS generation and

  2023-03-16

  

  There is a delicate balance between ROS generation and scavenging by the protective antioxidant defenses in the cell. Antioxidant systems present in the Syringin include enzymes like superoxide dismutase (SOD), catalases, glutathione peroxidases (GPxs) and peroxiredoxins (PRxs) (Fig. 3) [38]. SODs

• Over expression of the inflammatory cytokines MMPs and

  2023-03-16

  

  Over expression of the inflammatory cytokines, MMPs and COX-2 act as an important inducer of chronic inflammation. COX-2 catalyzes the biosynthesis of prostaglandins (PGs), and induced expression was observed in Fmoc-Asp(OtBu)-OH stimulated with pro-inflammatory cytokines or bacterial lipopolysacch

• br Materials and methods br Results and discussion

  2023-03-16

  

  Materials and methods Results and discussion Conclusion Funding This work was supported by the Canadian Institute of Health Research (CIHR) [grant number FDN-148413] to PS, the National Science and Engineering Research Council of Canada (NSERC) [grant number CRD-399680] to ÉM, and the FR

• Glu Gln Asp and Asn the main

  2023-03-15

  

  Glu, Gln, Asp, and Asn, the main herpes simplex virus 1 presented in the present study, are involved in nitrogen assimilation and transport processes within the plants. Furthermore, they are used to build up reserves during periods of nitrogen availability for subsequent use in growth, defense, and

• For the first series we decided

  2023-03-15

  

  For the first series we decided to verify the effects induced, on the ALR2 inhibitory properties, of an additional steric hindrance on the carbon in α position with respect to the carboxylic group, by introducing a methyl group (R2=Me). Therefore, we synthesized a series of new α-alanine derivatives

• Furthermore stress hormones can indirectly induce

  2023-03-15

  

  Furthermore, stress hormones can indirectly induce DNA damage, for example by altering DNA repair and transcriptional regulation of the cell cycle. It has been found that stress hormones induce the up-regulation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) and proto-oncogene cell div

16068 records 348/1072 page Previous Next First page 上5页 346347348349350 下5页 Last page