• Ning et al showed that LPC appeared to increase

  2022-08-10

  

  Ning et al. showed that LPC 18:1 appeared to increase insulin release through both GPR119-dependent and -independent mechanisms (Ning et al., 2008). In our study, we have shown that not only GPR119 but also GPR40 and GPR55 participate in LPC-stimulated insulin secretion (Fig. 4, Fig. 5) and target p

• The normal function of the FBPase enzyme

  2022-08-10

  

  The normal function of the FBPase enzyme is to catalyze the hydrolysis of F1,6BP to F6P. This activity is induced by diabetes and starvation and is increased in diabetic rats. The level of FBPase can be normalized by insulin, however, similar information is not available from diabetic patients. FBPa

• Recent studies in our laboratory

  2022-08-09

  

  Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his

• br Acknowledgments This study was financially supported

  2022-08-09

  

  Acknowledgments This study was financially supported by National Science Center Poland grant No DEC-2011/02/A/NZ4/00031 (KKK), Jagiellonian University Medical College (Poland) grants: K/ZDS/007130 (SM) and K/ZDS/007131 (SM), COST Action CA15135 (DŁ, HS, KKK) and DFG INST 208/664-1 FUGG (HS). Than

• Interestingly myorelaxation and the stimulation of cGMP prod

  2022-08-09

  

  Interestingly, myorelaxation and the stimulation of cGMP production are properties also reported for sGC stimulators, such as YC-1 and BAY 41–2272 (i.e., indazole compounds that were discovered in the 1990s) [35]. They relax aortic ring contractions induced by phenylephrine, and their effects are si

• Bioinformatic analysis revealed a putative

  2022-08-09

  

  Bioinformatic analysis revealed a putative coiled-coil SLD within CT229 which we show to be essential for intracellular replication and recruitment of Rab GTPases to the inclusion. Mutation of a single amino caffeic acid phenethyl ester residue in the SLD domain (CT229L120D) significantly reduced R

• The diversity of biological properties

  2022-08-09

  

  The ANP (1-11), rat of biological properties and interactions of GSK-3 have been reviewed recently (, , , , ). The interactions of GSK-3 in the signaling pathways induced by nutraceuticals is covered in the review by ) in this special issue of . GSK-3 is a frequent target of many nutraceuticals such

• br Introduction Initial studies of cancer metabolism in the

  2022-08-09

  

  Introduction Initial studies of cancer metabolism in the early 1920s showed that the cancer phenotype for glucose metabolism is unique, with increased abilities to take up glucose and produce lactate, even under aerobic conditions [1]. This pathway, called aerobic glycolysis or the Warburg effect

• INTRODUCTION Scar formation and tissue regeneration are

  2022-08-09

  

  INTRODUCTION Scar formation and tissue regeneration are opposite results of the wound healing process. Although fibrosis is more common after skin injury, full skin regeneration results in complete replacement of adnexa and function. Examples of tissue regeneration in mammalian systems include annu

• Introduction Non alcoholic hepatic steatosis is

  2022-08-09

  

  Introduction Non-alcoholic hepatic steatosis is characterized by the presence of steatosis in hepatocytes [1], which leads to the development of fatty liver [2]. It is strongly associated with obesity, insulin resistance, and type II diabetes [3]. They are major risk factors of non-alcoholic hepati

• br Materials and methods br Results br

  2022-08-09

  

  Materials and methods Results Discussion Disclosures Author contributions Acknowledgements Introduction Diabetes mellitus is one of the fastest growing chronic diseases worldwide, with an estimated prevalence of 382 million patients, of which about 90% have type 2 diabetes melli

• In the present study we aimed

  2022-08-09

  

  In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA ghrelin receptor antagonist of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-type

• br Results br Discussion br Materials and Methods br

  2022-08-09

  

  Results Discussion Materials and Methods Introduction Deoxyribonucleic LCL161 receptor (DNA) is among the most important biopolymers in living organisms alongside carbohydrates and proteins. DNA is a linear polymer consisting of four types of nucleobases, deoxyribose, and phosphate. The

• Mast cells isolated from mice and

  2022-08-09

  

  Mast SCH527123 mg isolated from mice and rats are able to take up histamine from the microenvironment (Day and Green, 1962, Cabut and Haegermark, 1966). It has been considered that the uptake of extracellular histamine into bone marrow-derived mast cell granules is mediated by two membrane transport

• br Experimental section br Acknowledgments MIN cells were ki

  2022-08-09

  

  Experimental section Acknowledgments MIN6 Birinapant were kindly provided by Dr. Junichi Miyazaki, Osaka University. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology of Japan (JP16H05099 and JP18H04609 to K.H., and JP16H06574 to T.U.),

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