• br Materials and methods br Results br Discussion

  2021-05-25

  

  Materials and methods Results Discussion One novel finding in our study is that CK2 inhibition preserved axon function and structure in WM against ischemia. Consistent with these findings, oligodendrocytes, astrocytes, myelin, and EDC.HCl were found to express CK2α. The robust expression p

• Ligand independent activation of neuronal nuclear estrogen r

  2021-05-25

  

  Ligand-independent activation of neuronal nuclear estrogen receptors may also continue to occur in absence of ovarian estrogens. AF-1 requires intracellular kinase cascade-dependent phosphorylation of specific residues in the A/B domain of nuclear estrogen receptors (Le Goff et al., 1994; Kato et al

• br Membrane receptor Indirect non genomic signaling

  2021-05-25

  

  Membrane receptor: Indirect non-genomic signaling As mentioned above, not all CMX001 australia responses fit the classical genomic model of steroid action. The observation of excessively fast estrogen-induced biological responses led to the development of the hypothesis that estrogen could be ac

• br Common features of TdT pol and pol TdT pol

  2021-05-24

  

  Common features of TdT, pol μ and pol λ TdT, pol μ and pol λ remain in a closed conformation throughout their catalytic cycle, contrary to pol β [24•, 53, 54•]. One possible explanation for this observation is that they have traded fidelity (which requires open-to-closed transition) for a very ti

• Another important issue in biosensors

  2021-05-24

  

  Another important issue in biosensors is to design a simple and potable detection strategy to meet the requirement of the point-of-care (POC) test applications. According to the recent research, by using invertase bromfenac for hydrolyzing sucrose into glucose, the range of personal glucometer has b

• Tamoxifen is included in the treatment protocol of ER breast

  2021-05-24

  

  Tamoxifen is included in the treatment protocol of ER+ breast carcinoma patients routinely. Although tamoxifen improves patients' survival, unfortunately a large number of ER+ patients don't response to tamoxifen treatment (Yager and Davidson, 2006). Detection of molecular markers which could take a

• ABH expression is elevated in prostate carcinomas and has

  2021-05-24

  

  ABH3 expression is elevated in prostate carcinomas and has been referred to as prostate cancer antigen-1 or PCA-1. ABH3/PCA-1 was proposed as a diagnostic marker for prostate cancers, and suggested as a possible therapeutic target [82]. However, the recent studies of ABH2 and ABH3-null mice indicate

• Cell lines which possess microglial

  2021-05-24

  

  Cell lines which possess microglial or neuronal properties are uncomplicated and convenient in vitro models for studying Irinotecan injury at the cellular and molecular levels. Microglial BV-2 cells are derived from the immortalized mouse microglia and exhibit many of the morphological, phenotypica

• br Discussion Our data demonstrate

  2021-05-24

  

  Discussion Our data demonstrate that the bicyclam AMD3100 strongly interacts with CXCR-4, whereas DS and AR177, two other compounds that also interfere with virus entry into the Busulfan (and interfere with virus binding), do not. AMD3100 is a unique compound in that it interferes with the chemo

• In a previous study we reported that

  2021-05-24

  

  In a previous study we reported that the systemic administration of the α1-adrenergic receptor antagonist prazosin attenuates the deficit in Folinic acid reward function associated with precipitated nicotine withdrawal (Bruijnzeel et al., 2010). One of the aims of the present experiments was to inv

• br Materials and methods br Results br Discussion In

  2021-05-24

  

  Materials and methods Results Discussion In this study, we uncovered a female-specific haplotype-MDD vulnerability association, by which a two-marker haplotype TG of rs4633-rs4680 may link to enhanced MDD risk in females. Female haplotype TG carriers were estimated to have a 9.17-fold incre

• br Introduction The cys loop ligand

  2021-05-22

  

  Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri

• br The estrogen receptors History and discovery In Elwood

  2021-05-22

  

  The estrogen receptors: History and discovery In 1958, Elwood Jensen discovered the estrogen receptor, the first receptor ever encountered for any hormone, by showing that reproductive female tissues were able to uptake estrogen from the circulation by binding to proteins. He later demonstrated t

• Introduction Hematopoietic stem cells HSCs in the adult bone

  2021-05-22

  

  Introduction Hematopoietic stem Menadione (HSCs) in the adult bone marrow (BM) provide all types of blood cells throughout life, while also self-renewing to maintain blood homeostasis. Blood/marrow stem cell transplantation is the most advanced method to cure patients suffering from hematological

• Probenecid br Conflict of interest statement br

  2021-05-22

  

  Conflict of interest statement Acknowledgement The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 278742 (Eurosarc) Introduction Pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like

16067 records 670/1072 page Previous Next First page 上5页 666667668669670 下5页 Last page