• br Method Detailed study protocol

  2021-05-11

  

  Method Detailed study protocol was reported previously. The ULTIMATE- HFrEF trial was approved by the Institutional Review Board of our hospital, and the study drug, udenafil, was approved as Investigational New Drug for treatment in patients with chronic HFrEF by Ministry of Food and Drug Safety

• It should be noted that not only glyphosate but

  2021-05-11

  

  It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the contain regulating proteins. Furthermore, we could not see a significant difference among this concentration range of glyphosate and E2 on other tes

• ERR induces the expression of P c

  2021-05-11

  

  ERRγ induces the expression of P450c17 in MA-10 cells and in mouse primary Leydig cells (Fig. 2). Deletion mutant analysis of putative ERRγ-binding sites in the P450c17 promoter suggested that only the proximal third site located between −269 bp and −136 bp within the P450c17 promoter is functional

• br Results br Discussion CCA is

  2021-05-11

  

  Results Discussion CCA is a fatal tumor originating from the intrahepatic bile duct and the prognosis is very poor (Hoyos et al., 2018). CCA is one of the most dangerous primary liver malignant tumors and the most common malignant tumor of the biliary tract worldwide. However, the underlying m

• br Conclusion In the last year

  2021-05-11

  

  Conclusion In the last year, significant advances in our understanding of ubiquitin transfer by IAPs and related E3 ligases have been made. The three crystal structures of the RING-bound E2~Ub show that the conjugate is bound by the RING domain in the closed conformation, where the I44-centered f

• fatty acid amide hydrolase br Discussion Of the age related

  2021-05-10

  

  Discussion Of the age-related differences in serum non-cholesterol sterols, we first deal with the cholesterol precursors. After birth, the markedly elevated serum desmosterol values decreased during the first year of life, and after 1 year of age they were similar between the other age groups. S

• br Menopausal hormone therapy from the beginning

  2021-05-10

  

  Menopausal hormone therapy, from the beginning to WHI Estrogen products have been used since the 1940s, with increasing prescription through the 1960s. First concerns appeared in the 1970s when oral treatment was linked to uterine cancer. Oral estrogens have traditionally been coupled with proges

• A French cohort study reported that micronized progesterone

  2021-05-10

  

  A French cohort study reported that micronized progesterone or didrogesterone used with oral or percutaneous estradiol showed no increase or decrease in the risk of breast cancer compared to synthetic progestins for at least 4 years of treatment [22] and even after 8 years [23]. Although the results

• br Experimental br Results and

  2021-05-10

  

  Experimental Results and discussion On the basis of the information obtained from the studies on RHA/TiO2 nanocomposites, it XL184 is expected that this reagent can be used as a catalyst for the promotion of the organic reactions. So this reagent was used in the promotion of the conversion of

• Herein we further established a dynamic DNA self assembly

  2021-05-10

  

  Herein, we further established a dynamic DNA self-assembly activated hemin-mimetic enzymes system by embedding DNA-hemin into an entropy-driven DNA-assembly for fluorescent biosensing. The entropy-driven dynamic DNA-assembly is one of the toehold-mediated isothermal strand displacement reactions, wh

• Breast cancer is the most common neoplasm in women

  2021-05-10

  

  Breast cancer is the most common neoplasm in women, with approximately 231,840 new cases of invasive breast cancer, 60,290 additional cases of in situ breast cancer and 40,290 deaths occurring in 2015 in the United States. Meanwhile, about 2350 men will be diagnosed with breast cancer, and 440 men w

• MuRF interacts with four and a half LIM domain FHL

  2021-05-10

  

  MuRF3 interacts with four-and-a-half LIM domain (FHL2) and γ-filamin leading to their degradation via UPS [64]. Conversely, abnormal aggregation of these proteins was observed in mice lacking MuRF3. Moreover, MuRF3-/- mice were found more prone to cardiac rupture after acute myocardial infarction (A

• Previous in vitro studies have demonstrated that DNA

  2021-05-10

  

  Previous in vitro studies have demonstrated that DNA-PK-deficient cell line (MO59J) is approximately 30-fold more sensitive to radiation than DNA-PK-proficient cell line (MO59K) [31]. Moreover, specific DNA-PK inhibitors SU11752 and wortmannin have been shown to sensitize GBM MK-2048 (MO59K) to radi

• Diclofenac ibuprofen and meloxicam are considered among the

  2021-05-10

  

  Diclofenac, ibuprofen, and meloxicam are considered among the most commonly used NSAIDs in many countries [4]. Cardiovascular events were reported with these NSAIDs in several clinical studies. In this study, we provide novel information that diclofenac and ibuprofen altered gene expression and may

• It is now widely known that blockade of CysLT receptors

  2021-05-10

  

  It is now widely known that blockade of CysLT1 receptors strongly inhibits antigen-induced bronchial contractions in specimens isolated from non-asthma subjects. However, this blockade is not complete as shown in the present study and in other literature.4, 15, 16 The results of the current study su

16067 records 678/1072 page Previous Next First page 上5页 676677678679680 下5页 Last page