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Among several variables that have been assessed
2020-07-29
Among several variables that have been assessed to determine spermatozoa quality, mitochondrial function has drawn attention because of its important role in sustaining spermatozoa motility, and, therefore, some investigators collect mitochondrial function data as additional information for conventi
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The results for the kinetic mechanism
2020-07-29
The results for the kinetic mechanism of LeuDH are consistent with previously reported data, except for the observed competitive inhibition by leucine on ketoleucine (Table 4). For reductive amination, there is wide agreement for a strictly ordered sequential mechanism of substrate binding, though t
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Alexidine dihydrochloride We found that both DDR and DDR ECD
2020-07-29
We found that both DDR1 and DDR2 ECD increased matrix mineralization as compared to native cells, with the effect of DDR2 ECD being more prominent. Both soluble (DDR2/ECD) and membrane-bound DDR2 ECD (DDR2/-KD), when compared to wild-type cells, induced larger mineral deposits. In this regard, a rec
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The similar functions of CCK and CRF
2020-07-29
The similar functions of CCK and CRF systems and their close localization raise a question: does the interaction between CCK and CRF systems exist and contribute to the modulation of anxiety-like behavior in animal models? Current knowledge in this field is quite limited. It was found that the chron
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DG content represented mol of total
2020-07-28
DG content represented 0.7–4mol% of total lipids in isolated cell membranes [41]. The concentrations of MG are 2–10-fold higher than those of DG in macrophages [42] and 3T3-L1 adipocytes [43]. Therefore, the contribution of the 1-MGK and 2-MGK activities of DGK may be considerably great in these MG-
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br Genotype phenotype correlations Genotype phenotype correl
2020-07-28
Genotype-phenotype correlations Genotype-phenotype correlations are limited. Compared with individuals with truncating variants, those with pathogenic missense variants in the adenosine triphosphate binding site had a milder disorder, some with ability to walk unaided, better hand use, and less r
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br Conflict of interest br Acknowledgements
2020-07-28
Conflict of interest Acknowledgements This work is funded by the National Institutes of HealthR01-GM069909 (YMC), Welch Foundation (I-1532; YMC), Leukemia and Lymphoma Society Scholar award (YMC), CPRIT (RP120352; YMC) and the UT Southwestern Endowed Scholars Program (YMC). We thank Q. Sun and
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br Role of CRF receptors
2020-07-28
Role of CRF2 receptors in the VTA in stress-induced relapse to cocaine seeking In 2005, the laboratory of Roy Wise [26] showed that CRF is released in the VTA after exposure to footshock in naïve rats and in cocaine-experienced rats. Furthermore, they showed that this released CRF is responsible
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As the proposed infrastructure has three layers see Fig
2020-07-28
As the proposed infrastructure has three layers (see Fig. 11), firstly, we evaluated the times measured in (A), (B), and (C), as shows Fig. 15. The time obtained in (A) is the execution time of the functions implemented in the independent layer server (COScore). Then, the time in (B) is derived from
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In humans individual differences in prefrontal dopamine
2020-07-28
In humans, individual differences in prefrontal dopamine are partially caused by the Val158Met single-nucleotide polymorphism on the catechol-O-methyltransferase gene (COMT). This gene controls activity of the COMT enzyme, which degrades extracellular catecholamines including dopamine. The Val varia
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Using four different Pichia Pink strains and
2020-07-28
Using four different Pichia Pink strains and two different pPink vectors (Table 1), eight different yeast strains were obtained. The level of recombinant proteins produced was compared in the eight strains by P4H radioactive enzymatic assay. The highest enzymatic activity was obtained in the αβH4 st
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There has been a notion
2020-07-28
There has been a notion of “CMV vs. leukemia effect” since the 1980s and recent studies by Elmaagacli et al and Green et al suggested a beneficial effect of CMV reactivation on leukemia relapse in patients with AML [12,13]. In our study, CMV reactivation had no effect on relapse after allo-HSCT. Thi
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To address this question it is necessary to mention
2020-07-28
To address this question, it is necessary to mention telomeric repeat–containing RNA (TERRA) and telomeric repeat factor 2 (known as TRF2 or TERF2). Telomeric repeat-containing RNA (TERRA) is a large non-coding RNA in mammalian cells, which forms an integral component of telomeric heterochromatin [1
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When we analyzed the cervical mucosa and stroma in
2020-07-27
When we analyzed the cervical mucosa and stroma in late equine pregnancy, expression levels for ESR1 and PGR were lower than those observed in estrus and diestrus. During this stage of pregnancy, progesterone metabolites such as 5α-dihydroprogesterone (5α-DHP) are approximately three times higher th
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br Acknowledgement This research was
2020-07-27
Acknowledgement This research was partly funded by the National Science Foundation\'s Long-Term Ecological Research Program (DEB 1027253), by the National Science Foundation\'s Geobiology and Low Temperature Geochemistry Program (Award no. 1630399), by the Department of Energy Great Lakes Bioener
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