• We present a case report of a patient with chronic

  2019-05-27

  

  We present a case report of a patient with chronic myeloid leukemia (CML) who developed bilateral renal artery stenosis during tyrosine kinase inhibitor (TKI) therapy. Only a few reports associate TKIs with acute renal failure, and renovascular hypertension has not been previously described. Reports

• br Conformational control inhibition Conformational escape r

  2019-05-27

  

  Conformational control inhibition Conformational escape resistance is a phenomenon where point mutations (such as T315I) drive the Abl kinase toward the active type I state. “Switch-control inhibitors” bind in a non-ATP-competitive fashion to residues (E282, R386) the Abl protein uses to switch b

• order T-5224 br Conclusion br Authors contribution br

  2019-05-27

  

  Conclusion Authors’ contribution Competing interests Acknowledgments Case report Imatinib has radically changed prognosis in chronic-phase Chronic Myeloid Leukemia (CML), with 90% overall survival rate at 8yrs, and 40–70% of patients achieving a stable MMR [1]. Even better results hav

• Recently a reciprocal fusion between YPEL yippee like and PP

  2019-05-27

  

  Recently, a reciprocal fusion between YPEL5 (yippee-like 5) and PPP1CB (serine/threonine protein phosphatase-1 beta catalytic subunit) was described to be exclusively expressed in more than 90% of primary CLL samples [5] and not in control samples or samples from patients with other hematological ma

• But consider the alternative outcomes

  2019-05-27

  

  But consider the alternative outcomes of so-called virtuous plate-clearing. If the additional portion does not displace other consumption—ie, the amount eaten subsequently is not reduced—then total consumption will have increased. A lack of displacement means no reduction in demand for agricultural

• The recently published global consensus recommendations on

  2019-05-27

  

  The recently published global consensus recommendations on prevention and management of rickets advocate for the eradication of rickets and osteomalacia through implementation of national supplementation and food fortification programmes containing vitamin D, calcium, or both. On the basis of high-q

• Since the progressive introduction of the meningococcal

  2019-05-27

  

  Since the progressive introduction of the meningococcal serogroup A conjugate vaccine in meningitis belt countries via mass vaccination campaigns of 1–29 year olds starting in 2010, a remarkable effect of the vaccine has been observed. Similar to other conjugate vaccines, MenAfriVac has demonstrated

• br We have reviewed the

  2019-05-27

  

  We have reviewed the issues and arguments presented by Wang et al. In fact, we have well-clarified these issues in “Discussion” section of our original article. The aim of our study was to investigate the expression of maternal antineuronal ANA 12 Supplier and their role in childhood autism spec

• protease inhibitor There were differentially expressed genes

  2019-05-24

  

  There were 3151 differentially expressed genes identified from the transcriptome profiling data of 497 patients (Fig. 2). Among these differentially expressed genes, 2190 genes were found to be upregulated in the group with infiltrating lymphocytes ≥1%. As shown in Table 2, these genes were enriched

• br Conclusions br Limitation br Acknowledgments This researc

  2019-05-24

  

  Conclusions Limitation Acknowledgments This research was supported in part by the China Postdoctoral Science Foundation (Nos. 2013M542478 and 2015T81139), a Grant (no. 2014FB059) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical Uni

• The aim of this cross sectional study

  2019-05-24

  

  The aim of this cross-sectional study was to investigate the relationships between patient characteristics and antithrombotic therapy prescribed for the prevention of ischemic stroke and systemic embolism in patients with NVAF in clinical practice. Additionally, because the data were to be used to c

• Mismo fen meno se observa en El Museo

  2019-05-24

  

  Mismo fenómeno se observa en El Museo Mexicano, publicación ciertamente exitosa y donde se dieron cita los escritores más sobresalientes de la literatura mexicana decimonónica entre los años 1843 hasta 1846. El epígrafe que remata la portada constituye, en términos programáticos, todo una declaració

• sigma receptor br Should child growth replace

  2019-05-24

  

  Should child growth replace diarrhoea as the primary child health outcome for sanitation trials? We appreciate Derek Headey\'s comment in relation to our trial that the window of opportunity to plausibly affect growth faltering is from in utero up to 24 months, and therefore that sanitation trials

• br As outlined in in October my vision for

  2019-05-24

  

  As outlined in in October, 2016, my vision for WHO can be summed up in five words: equity, rights, responsiveness, evidence, and partnership. In this sitagliptin phosphate context, I am pleased to respond to the authors of the open letter in , on the leadership role that WHO must play in tackling

• This population based study demonstrates

  2019-05-24

  

  This population-based study demonstrates that interventions must change attitudes regarding violence in the home and society, promote positive parenting practices, and tackle the inequality that allows the normalisation of violence and patriarchal power over women and children. Violence does not occ

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