• The mechanism leading to the gelatinous transformation may i

  2019-05-13

  

  The mechanism leading to the gelatinous transformation may involve inhibition of tyrosine kinase activity by tyrosine kinase inhibitors (TKI) leading to blockage of downstream signal pathways, affecting extracellular matrix deposition, adipocyte differentiation and angiogenesis. Moreover, the catabo

• Finally it is highly interesting to note

  2019-05-13

  

  Finally, it is highly interesting to note that human endogenous retroviruses have been suggested to play a role in the etiology of both MS and MPN [7,9]. Supporting this notion, both MS and MPN are treated with type 1 interferons, which have very potent antiviral and immunomodulating effects. Indeed

• MG-132 Introduction Myelodysplastic Syndrome MDS is a hetero

  2019-05-13

  

  Introduction Myelodysplastic Syndrome (MDS) is a heterogeneous clonal disorder characterized by ineffective hematopoeisis and propensity for transformation into Acute Myelogenous Leukemia (AML). The Revised International Prognostic Scoring System (R-IPSS) is an accepted model used to predict overal

• National coverage trends were accelerated because of the con

  2019-05-13

  

  National coverage trends were accelerated because of the contribution of trends in the two poorest quintiles. In middle-income countries, for example, the estimated increase in national trends was around 25% faster as a result of the contribution of poor populations. Increases in coverage in rural a

• HBeAg positive patients older than

  2019-05-13

  

  HBeAg-positive patients older than 40 years with persistently high or high to normal ALT levels may be diagnosed with significant hepatic necroinflammation or fibrosis. During treatment, the clinical significance of timing of HBeAg loss or seroconversion remains unclear. However, a longer duration o

• integrin inhibitors Polymorphic VT VF storms can

  2019-05-13

  

  Polymorphic VT/VF storms can occur in patients with severe integrin inhibitors failure, independent of their underlying causes. Recent experimental studies using a pacing-induced heart failure model showed that heart failure facilitates acute shortening of the APD immediately after VF termination [

• The patient had experienced cardiopulmonary arrest

  2019-05-13

  

  The patient had experienced cardiopulmonary arrest because of PEA and bradycardia at least twice while on oral treatment for variant angina, but neither ventricular fibrillation nor ventricular tachycardia was apparent. Spontaneous attacks occurred despite the use of an oral calcium blocker, and low

• A year old male was referred to our

  2019-05-13

  

  A 59-year-old male was referred to our hospital in cardiogenic shock. A 12-lead electrocardiogram showed abnormal Q-waves in V1–V4 leads and complete atrioventricular block; the patient was diagnosed with acute myocardial infarction (AMI) (Fig. 1). Upon arrival, the patient was unconscious, and his

• br Initially extrastimulation from the RV at a basic CL

  2019-05-13

  

  Initially, extrastimulation from the RV at a basic CL of 600ms showed no jump-up phenomenon and VA conduction block at a coupling interval of 480ms (not shown in the figure). The antegrade AVN conduction was evaluated by extrastimulation from the HRA and the ostium of the CS (CSp) at a basic CL of

• br Discussion Prehabilitation is a program to

  2019-05-10

  

  Discussion “Prehabilitation” is a program to enhance functional capacity and psychological health to enable patients to withstand an upcoming stressor, e.g. surgery. It is intended to reduce treatment-related morbidity and/or mortality, to decrease length of hospital stay and/or re-admission, and

• br Conflict of interest br Introduction Gastric cancer

  2019-05-10

  

  Conflict of interest Introduction Gastric cancer is a major cause of cancer deaths worldwide, particularly in East Asia. Metastatic gastric cancer is associated with poor outcomes. The median overall survival of metastatic gastric cancer ranges from 9 to 13 months despite treated with systemic

• br Bisphosphonate use and breast cancer

  2019-05-10

  

  Bisphosphonate use and breast cancer risk BPs are commonly used in the management of postmenopausal osteoporosis. They consist of two phosphate groups, which give them a high affinity to bone. They attach to bone at exposed calcium hydroxyapatite binding sites, which are most accessible at sites

• Introduction The Yoga My Heart Study was a

  2019-05-10

  

  Introduction The Yoga My Heart Study was a single center study that brought to light the therapeutic impact a noninvasive, medication-free intervention has on a costly disease. Atrial fibrillation (AF) is a common cardiac arrhythmia that affects two to three million people worldwide. It is associat

• Introduction Atrial fibrillation AF is the most common cardi

  2019-05-10

  

  Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia managed in clinical practice and the most common arrhythmia requiring hospitalization [1,2]. Thromboembolism occurs with similar incidence, regardless of the form of AF [3,4]. AF management includes anticoagulation to preve

• read review Despite our best efforts the cause of SCD

  2019-05-10

  

  Despite our best efforts, the cause of SCD in young individuals is sometimes not established; no cause is identified in up to 40% of cases. Importantly, whether a cause of death is established or not, the possibility of an underlying inherited cardiac disorder remains in many cases, including the po

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