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          br Contributors br Funding br Conflict of interest2019-06-21  Contributors Funding Conflict of interest Patient consent Ethics approval Acknowledgment Introduction Perforation of a cardiac chamber has been reported as a relatively rare complication of pacemaker implantation; in particular, attachment of the active-fixation atrial lead to t 
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          br Conclusions and future perspectives2019-06-21  Conclusions and future perspectives Conflict of interest Author’s contributions Introduction Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two opposing mechanisms involved in regulating the chemical and functional homeostasis of end 
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          br Conclusions and future perspectives2019-06-21  Conclusions and future perspectives Conflict of interest Author’s contributions Introduction Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two opposing mechanisms involved in regulating the chemical and functional homeostasis of end 
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          TNP-470 Two months from the initiation of dasatinib abnormal2019-06-21  Two months from the initiation of dasatinib, abnormal FDG uptake of the left femur tumor had disappeared. Examination of peripheral blood and the bone marrow examination showed that a complete cytogenetic response was achieved and a ratio of BCR-ABL to ABL on the international scale was 0.21%. Her d 
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          br Material and methods br Results2019-06-21  Material and methods Results Discussion The present study provides clinical, molecular, and in vitro electro-physiological evidence that a rare SNP (KCNE1-D85N) can act as a genetic modifier in LQTS. In general, SNPs are thought to be non-pathological, but some have been reported to modify 
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          anti fungal Lead failures are classified as either structura2019-06-21  Lead failures are classified as either structural lead failures or electrical lead failures, and failures of 8F single coil leads are more frequently reported. Structural failures occur with a reported incidence of 14–34% and are evident as cable exteriorization in fluoroscopy studies [6,7]. Electri 
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          Based on the methodology used in previous studies2019-06-21  Based on the methodology used in previous studies, the EGM source for the Wavelet algorithm has been nominally programmed as the Can-RV coil EGM [13]. As the nominal EGM source includes the generator, myopotentials induced due to body motion or other muscle activity are likely to influence the arrhy 
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          (R)-PFI 2 hydrochloride br ECM cancer and metastasis For cel2019-06-21  ECM, cancer and metastasis For (R)-PFI 2 hydrochloride to become cancerous they must acquire the ability to survive, grow and invade leading to malignant transformation, tumour formation and ultimately overt secondary metastasis. Abnormal ECM can promote these abilities and is a well-documented h 
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          Competing pressures for resources across sectors however mea2019-06-20  Competing pressures for resources across sectors, however, mean that increasing the proportion of resources for health will be difficult. Efficiency gains in the health sector could help to make the case for more investment. Countries need to tackle major sources of inefficiency by doing more of the 
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          Al mismo tiempo que el2019-06-20  Al mismo tiempo que el joven no cree en la matanza, actualiza antiguos estereotipos reforzados por imágenes que construyen el imaginario social. ¿Qué otra cosa hace Altunaga, sino problematizar la axiología revolucionaria del fin del racismo cuando pone en boca del barrendero la siguiente reflexión? 
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          People in LMICs are disproportionately exposed to2019-06-20  People in LMICs are disproportionately exposed to severe acute kidney injury and have substantially less access to effective treatment than do people in higher-income countries. Framing acute kidney injury as a driver of substantial inequity in disease risk and mortality in low-resource countries, t 
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          In terms of outcome based assessments2019-06-20  In terms of outcome-based assessments, we analyzed the primary outcomes in both the 7-day and in-hospital mortality, to evaluate further whether the cause of death would be related to acute illness or chronic comorbidities, and furthermore to ensure care quality in both units. Illness severity and t 
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          Holter ECG monitoring was performed after the patient consum2019-06-20  Holter ECG monitoring was performed after the patient consumed 180mL of sake (alcohol) each night in both the DDD-R and DDD-CLS modes. The mean HR in the DDD-CLS mode (68bpm) was similar to that (71bpm) in the DDD-R mode, but during sleep, the atrial pacing ratio (43.2%) in DDD-CLS was significantly 
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          Effective medical management of cutaneous2019-06-20  Effective medical management of cutaneous leukotriene receptor antagonists arising from internal malignancy is usually difficult. Systemic chemotherapy and local excision or radiation therapy may be considered. As for metastatic ampulla of Vater cancer, the more recent histological differentiation i 
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          br Introduction Patients with advanced breast prostate lung2019-06-20  Introduction Patients with advanced breast, prostate, lung and colo-rectal cancer frequently develop bone metastases (BMs). These lesions may be asymptomatic or may cause pain, pathologic fractures, malignant hypercalcemia, epidural spinal cord compression and/or shorten survival [1]. The underly 
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